Faculty Members

Kislay Kumar Sinha
(Associate Professor)

National Institute of Pharmaceutical Education & Research,
(NIPER), Hajipur-844 102, Bihar, India.
Mobile :+91-9279133837
Emails: kksinha@gmail.com or kksinha@yahoo.com


Educational qualifications:

Ph.D. Biotechnology Institute of Microbial Technology / Panjab University Chandigarh.

Master of Science (Biotechnology) Madurai Kamaraj University, Madurai.

Bachelor of Science in Agriculture and Animal Husbandry Govind Ballabh Pant University of Agriculture & Technology, Pantnagar

 

Professional experience:
Associate Professor in Department of Biotechnology, National Institute of Parmaceutical Education and Research (NIPER), Hajipur from February 2015 till present.
Assistant Professor in Department of Biotechnology, National Institute of Parmaceutical Education and Research (NIPER), Hajipur from February 2009 to February 2015.
Research Associate in Department of Molecular Pharmacology, St. Jude Children’s Research Hospital, Memphis, TN from September 2007 to January 2009.
Department of Medicine, Division of Hematology and Oncology, University of Illinois at Chicago as Instructor from May 2006 to September 2007.
Department of Pathology and Cancer Center, University of Illinois at Chicago as Instructor from 2003 to April 2006.
Department of Pathology and Cancer Center, University of Illinois at Chicago as Visiting research Scholar from 2002 to 2003

Institute of Microbial Technology, Chandigarh as Project Assistant in 2001, Senior Research Fellow from 1998 to 2001 and Junior Research Fellow from 1996 to 1998.

 

Research publications:
Rina Kumari, Mohd. Imran Khan, Sourav Bhowmick, Kislay K. Sinha, Neeladri Das, Prolay Das (2017) Self-assembly of DNA-porphyrin hybrid molecules for the creation of antimicrobial nanonetwork. Journal of Photochemistry and Photobiology B: Biology 172: 28–35.
Pravin K. Jha, Mohd. Imran Khan, Anshul Mishra, Pradeep Das, Kislay K. Sinha (2017) HAT2 Mediates Histone H4K4 Acetylation and Affects Micrococcal Nuclease Sensitivity of Chromatin in Leishmania donovani. PLOS ONE (Accepted for publication).
Kislay K. Sinha, Nagesh Peddada, Pravin K. Jha, Anshul Mishra, Krishna Pandey, Vidya Nand Ravi Das, Ashish, Pradeep Das (2017) Plasma Gelsolin Level in HIV-1-Infected Patients: An Indicator of Disease Severity. AIDS Res Hum Retroviruses. 33(3):254-260.
Seema Singh, Anshul Mishra, Rina Kumari, Kislay K. Sinha, Manoj K. Singh and Prolay Das (2017) Carbon dots assisted formation of DNA hydrogel for sustained release of drug. Carbon 114, 169-176.
Savita Sainia,, Ayan Kumar Ghosh, Ruby Singh, Sushmita Das, Kumar Abhishek, Ajay Kumar, Sudha Verma, Abhishek Mandal, Abul Hasan Sardar, Bidyut Purkait, Ashish Kumar, Kislay Kumar Sinha and Pradeep Das (2016) Glucose deprivation induced upregulation of phosphoenolpyruvate carboxykinase modulates virulence in Leishmania donovani. Molecular Microbiology 102(6):1020-1042.
Seema Singh, Pravin Jha, Vandana Singh, Kislay Sinha, Sahid Hussain, Manoj K. Singh and Prolay Das (2016) A quantum dot–MUC1 aptamer conjugate for targeted delivery of protoporphyrin IX and specific photokilling of cancer cells through ROS generation. Integrative Biology 8, 1040-1048.
Vijayamahantesh, Amit A, Kumar S, Dikhit MR, Jha PK, Singh AK, Sinha KK, Pandey K, Das VNR, Das P, Bimal S (2016) Up regulation of A2B adenosine receptor on monocytes are crucially required for immune pathogenicity in Indian patients exposed to Leishmania donovani. Cytokine 79: 38-44.
Singh J, Srivastava A, Jha P, Sinha KK, Kundu B (2015) L-Asparaginase as a new molecular target against leishmaniasis: insights into the mechanism of action and structure based inhibitor design. Molecular Biosystems 11(7):1887-96
Sardar AH, Kumar S, Kumar A, Purkait B, Das S, Sen A, Kumar M, Sinha KK, Singh D, Equbal A, Ali V, Das P. (2013) Proteome changes associated with Leishmania donovani promastigote adaptation to oxidative and nitrosative stresses. Journal of Proteomics 81:185-99.
Vitalyi Senyuk, Kislay K. Sinha, Donglan Li, Ciro R. Rinaldi, Sastry Yanamandra, and Giuseppina Nucifora. (2007) Repression of RUNX1 activity by EVI1: a new role of EVI1 in leukemogenesis. Cancer Research 67: 5658-66.
Donglan Li, Kislay K. Sinha*, Maher Abdul Hay, Ciro R. Rinaldi, Yogen Saunthararajah and Giuseppina Nucifora. (2007) Runx1-Runx1 interaction modulates Runx1 activity and function. Journal of Biological Chemistry 282(18): 13542-51.
* Co-first author.
Leopoldo Laricchia-Robbio, Raffaella Fazzina, Donglan Li, Ciro R. Rinaldi, Kislay K. Sinha, Soumen Chakraborty, and Giuseppina Nucifora. (2006) Point mutations in two EVI1 Zn fingers abolish EVI1-GATA1 interaction and allow erythroid of murine bone marrow cells. Molecular and Cellular Biology. 26(20): 7658-66.
Fady M. Mikhail, Kislay K. Sinha, Yogen Saunthararajah and Giuseppina Nucifora. (2006) Normal and transforming functions of RUNX1: a perspective. Journal of Cellular Physiology. 207(3): 582-93.
Vitalyi Senyuk, Kislay K. Sinha and Giuseppina Nucifora. (2005) Corepressor CtBP1 interacts with and specifically inhibits CBP activity.†Archives of Biochemistry and Biophysics. 441(2): 168-73.
Soumen Chakraborty, Kislay K. Sinha*, Vitalyi Senyuk and Giuseppina Nucifora. (2003) SUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivo. Oncogene. 22(34): 5229-37.* Co-first author.
Vitalyi Senyuk, Kislay K. Sinha, Soumen Chakraborty, Silvia Buonamici and Giuseppina Nucifora. (2003) P/CAF and GCN5 acetylate the AML1/MDS1/EVI1 fusion oncoprotein. Biochemical and Biophysical Research Communications. 307(4): 980-6.

M Thungapathra, Amita, Kislay K. Sinha, Saumya Ray Chaudhuri, Pallavi Garg, Thandavarayan Ramamurthy, Gopinath Balakrish Nair, Amit Ghosh. (2002) Occurrence of antibiotic resistance gene cassettes aac(6')-Ib, dfrA5, dfrA12, and ereA2 in class I integrons in non-O1, non-O139 Vibrio cholerae strains in India. Antimicrob Agents Chemother. 46(9): 2948-55.

 

Abstracts/posters:

Kislay K. Sinha, Donglan Li, Maher Abdul Hay, Giuseppina Nucifora Autoregulation of RUNX1 Activity by Homodimerization. The forty-eight Annual meeting and exposition, American Society of Hematology. December 9-12, 2006.

Vitalyi Senyuk, Kislay K. Sinha, Sastry Yanamandra, Giuseppina Nucifora EVI1 Interacts with and Represses RUNX1: A Novel Mechanism of Deregulated Hematopoiesis in EVI1-Positive Hematopoietic Cells. American Society of Hematology. December 9-12, 2006.

Kristine Baraoidan, Vinzon Ibanez, Chetna Mittal, Habte Yimer, Suman Chakraborty, Kislay Sinha, Steven Ackerman, Giuseppina Nucifora, Yogenthiran Saunthararajah A Possible Mechanism for Synergy in Transcriptional Activation between AML1 and PU.1: Exclusion of the Co-Repressor CBFA2T3 (ETO-2, MTG16) The forty-sixth Annual meeting and exposition, American Society of Hematology. December 6-9, 2004.

Kislay K. Sinha, Soumen Chakraborty, Vitalyi Senyuk, Giuseppina Nucifora. The Leukemia Associated Transcription Factor AML1 Interacts with SUV39H1 and Is Methylated In Vivo. The forty-fifth Annual meeting and exposition, American Society of Hematology. December 6-9, 2003

Vitalyi Senyuk, Kislay K. Sinha, Silvia Buonamici, Giuseppina Nucifora Interaction of the Leukemia-Associated Protein AML1/MDS1/EVI1 (AME) with P/CAF and GCN5 Leads To Acetylation of AME and Abrogation of AME-Mediated Transcription Repression. The forty-fifth Annual meeting and exposition, American Society of Hematology. December 6-9, 2003

Amit Ghosh, Thungapathra, M., Amita, Kislay K. Sinha, Saumya Ray Chaudhuri, Pallavi Garg, Thandavarayan Ramamurthy and Gopinath Balakrish Nair Distribution of class I integrons and SXT elements in non-O1, non-O139 Vibrio cholerae isolated from the patients and from the environment in Calcutta, India, during 1997-98. The thirty-seven joint conference of US-Japan cooperative medical science program Cholera and other bacterial enteric infectious panel. December 17 ― December 19, 2002
Genbank Sequences:
AF455254, AF512546, AF512547, AY103455, AY103456, AY103457, AY103458, AY103459, AY103460, AF452449 and NC003311
Memberships:
Associate member of American Society of Hematology
American Association for Cancer Research
 
     
     
     
 
     
   
       
 
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