Faculty Members
 

Dr. Mukesh Chourasia
Senior Lecturer
Department of Pharmacoinformatics

National Institute of Pharmaceutical Education & Research,
(NIPER), Hajipur-844 101, Bihar, India.

Mobile :+91-9576161682
Email: mchourasia@gmail.com

Educational qualifications:

Ph.D. in Biochemistry (Molecular Modeling), CSIR-Indian Institute of Chemical Technology, Hyderabad, India.

One-Year Post Graduate Diploma in Bioinformatics, Bioinformatics Institute of India, Noida. (2002-2003)

Masters in Applied Biochemistry, College of Life Sciences, Cancer Hospital and Reseach Institute, Jiwaji University, Gwalior. (1999-2001)

 

Professional experience:
Senior Lecturer, Department of Pharmacoinformatics, NIPER-Hajipur. (2014-present)
Post-doctoral, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel.

Post-doctoral, The Lise Meitner-Minerva Center for Computational Quantum Chemistry, Institute of Chemistry, The Hebrew University of Jerusalem, Israel.

Scholarships/Awards:
1.
PBC Fellowships for Outstanding Post-doctoral Researchers, The Hebrew University of Jerusalem, Israel - 2012/2013/2014.
2.
Boehringer Ingelheim Fonds (BIF) funding (2007) for the project entitled "Molecular Modeling Approaches: Insight into the Mechanism of Ca2+ and H+ transport across the transmembrane of Ca2+-ATPase (SERCA)" with Prof Matthias Ullmann, Head, Structural Biology/Bioinformatics Group, Bayreuth University, Germany.
3.
Qualified CSIR/UGC-NET held in June 2003.
4.
Accelrys Certified Professional course in “Protein Modeling and Rational Drug Designing” from BioCampus, GVK Bio Sciences Pvt. Ltd, Hyderabad in 2003.
5.

Qualified National Talent Search Contest in class X at all India level.

 

Research Publications: *Corresponding Author
1.
Akbar Pathan, Bhavana Panthi, Zahid Khan, Purushotham Reddy Koppula, Mohammed Saud Alanazi, Narasimha Reddy Parine, Sachchidanand, Mukesh Chourasia*. Lead Identification for the K-Ras Protein: Virtual Screening and Combinatorial Fragment Based Approaches. OncoTargets and Therapy. 2016; 9: 2575-2584.
2.

Ewa Kozelaa, Christeene Haj, Lumir Hanuš, Mukesh Chourasia, Avital Shurki, Ana Juknat, Nathali Kaushansky, Raphael Mechoulam, Zvi Vogel. HU-446 and HU-465, derivatives of the non-psychoactive cannabinoid cannabidiol, decrease the activation of encephalitogenic T cells. Chem. Biol. Drug. Des. 2016; 87: 143-153.

3.
Anil K. Singh, Sadiq Umar, Sharayah Riegsecker, Mukesh Chourasia, Salahuddin Ahmed. Regulation of TAK1 activation by epigallocatechin-3-gallate in RA synovial fibroblasts: suppression of K63-linked autoubiquitination of TRAF6. Arthritis Rheumatol., 2016; 68: 347-358. [Published as cover page article]
4.
Reem Smoum, Saja Baraghithy, Mukesh Chourasia, Aviva Breuer, Naama Mussai, Malka Attar-Namdar, Natalya M. Kogan, Bitya Raphael, Daniele Bolognini, Maria G. Cascio, Pietro Marini, Roger G. Pertwee, Avital Shurki, Raphael Mechoulam, and Itai Bab. CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency. Proc. Natl. Acad. Sci. U S A. 2015; 112: 8774-8779.

5.
Tamar Ansbacher, Mukesh Chourasia, Avital Shurki. Copper-chaperones with di-coordinated Cu(I) - unique protection mechanism. Proteins: Structure, Function, and Bioinformatics. 2013; 81:4011-4019.
6.
Dandamudi U., Costantino Zazza, Wenzhen Lai, Mukesh Chourasia, Lucy Waskell, Sason Shaik. A Single Site mutation (F429H) Converts the Enzyme CYP 2B4 into a Heme Oxygenase: A QM/MM Study. J. Am. Chem. Soc. 2012; 134:4053–4056.
7.
Mukesh Chourasia, G. Narahari Sastry. The Nucleotide, Inhibitor, and Cation Binding Sites of P-type II ATPases. Chem. Biol. Drug. Des. 2012; 79:617–627. [Published as cover page article]
8.
Mukesh Chourasia, G. Madhavi Sastry, G. Narahari Sastry. Aromatic − Aromatic Interactions Database, A2ID: An Analysis of Aromatic -Networks in Proteins. Int. J. Biol. Macromol. 2011; 48:540–552.

9.
Hemant Kumar Srivastava, Mukesh Chourasia, Devesh Kumar, G. Narahari Sastry. Comparison of Computational Methods to Model DNA Minor Groove Binders. J. Chem. Inf. Model. 2011; 51:558–571.
10.
Ahmed Kamal, Rajesh V. C. R. N. C. Shetti, M. Janaki Ramaiah, P. Swapna, K. Srinivasa Reddy, A. Mallareddy, M. P. Narasimha Rao, Mukesh Chourasia, G. Narahari Sastry, Aarti Juvekar, Surekha Zingde,d Pranjal Sarma, S. N. C. V. L. Pushpavalli, Manika Pal-Bhadra. Carbazole–pyrrolo[2,1-c][1,4]benzodiazepine conjugates: design, synthesis, and biological evaluation. Med. Chem. Commun. 2011; 2:780–788.
11.
Ahmed Kamal, K. Srinivasa Reddy, Chatla Srinivas, Manika Pal-Bhadra, Mukesh Chourasia, G. Narahari Sastry, et. al. Synthesis, DNA-binding affinity and anticancer activity of benzothiazole/benzoxazole-pyrrolo[2,1-c][1,4]benzodiazepine hybrids. Bioorg. Med. Chem. 2010; 18:4747–4761.
12.
Ahmed Kamal, Rajender, D. Rajasekhar Reddy, MK. Reddy, G. Balakishan, TB Shaik, Mukesh Chourasia, G. Narahari Sastry. Remarkable enhancement in the DNA-binding ability of C2-fluoro substituted pyrrolo[2,1-c][1,4]benzodiazepines and their anticancer potential. Bioorg. Med. Chem. 2009; 17:1557–1572.

13.

Mukesh Chourasia, G. Madhavi Sastry, G. Narahari Sastry. Proton binding sites and conformational analysis of H+K+-ATPase. Biochem. Biophys. Res. Commun. 2005; 336:961–966.

 

Book-Chapter

1. MA Sreshty, Mukesh Chourasia, USN. Murthy, G. Narahari Sastry. Homology modelling and inhibitor based active site validation of the P. falciparum malonyl CoA: ACP transacylase. In Book entitled “Vector-Borne Diseases: Epidemiology and Control” edited by: B.K. Tyagi. 2008; ISBN 81-7233-541-0.

 

Conferences and Workshops
1.
Two-day (Mar 15th-16th 2016) workshop on “Intellectual Property Right”, sponsored by IPR Unit of ICMR, organized at RMRIMS, Patna.

2.
“Epigallocatechin-3-Gallate (EGCG) Facilitates TAK1 Nuclear Translocation and Its Interaction with p300 to Inhibit Histone Acetylation in Human RA Synovial Fibroblasts” at ACR/ARHP Annual Meeting, November 6th –11th, 2015 held at San Francisco, CA.
3.
IMMUNOCON-2015, 42nd Annual Conference of Indian Immunology Society, organized by Rajendra Memorial Research Institute of Medical Sciences (ICMR), October 9th-11th, 2015 at Patna, India.
4.
“Copper Chaperones: Cu(I)-Ligands Coordination Quest” at The Lise Meitner Minerva Center Computational Chemistry Symposium, November 3rd 2013, held at Weizmann Institute of Science, Israel.
5.
The First French-Israeli Inter-Academy Meeting in Chemistry on “Theoretical and Computational Chemistry and Biophysics”, May14th–15th 2012, held at The Israel Academy of Science and Humanities, Jerusalem, Israel.

6.
“Hydride Transfer Mechanism Governs the Catalytic Process of Amine Oxidation in Monoamine Oxidase A & B: A QM/MM Study” at The Lise Meitner Minerva Center Computational Chemistry Symposium, March 11th 2012, held at Hebrew University, Jerusalem, Israel.
7.
“O2 Activation Mechanism of Tryptophan Hydroxylase Enzyme: A QM/MM Study” at The Lise Meitner Minerva Computational Chemistry Symposium, March 11th 2012, held at Hebrew University, Jerusalem, Israel.
8.
The Lise Meitner Minerva Computational Chemistry Symposium”, November 22nd 2012, held at Hebrew University, Jerusalem, Israel.
9.

SERC summer school in “Modeling and Informatics in Drug Design”, June 30th-18th, 2008, held at National Institute of Pharmaceutical Education and Research, Mohali, Punjab, India.

10.

“Ca2+-ATPase: Molecular Insight into the Antiport (Ca2+/H+) Mechanism and Effect of TG1 and BHQ” at DST-DFG Sponsored Indo-German Conference “Modeling Chemical and Biological (Re)activity”, September 26-29th, 2007, held at Indian Institute of Chemical Technology, Hyderabad, India.

11.

“Homology modeling and molecular dynamics simulations on gastric proton pump and the calcium pump (SERCA1a)” at Joint ACS-CSIR International Conference on “Advances in Organic Chemistry and Chemical Biology” (AOCCB 2006), January 11-12, 2006, held at Indian Institute of Chemical Technology, Hyderabad, India.

12.
Workshop on “Molecular Modelling and Pharmainformatics”, November 1-5, 2004, held at National Institute of Pharmaceutical Education and Research, Mohali, Punjab, India.
13.
Short term course on “Introduction to Bioinformatics and its Applications”, March 21-22, 2003 held at Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology, Delhi, India.
 
 
     
 
     
   
       
 
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