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Department Of pharmacology & Toxicology

Department of Pharmacology and Toxicology has the facilities to carry out pharmacological screening of NCEs. The department can enter into project collaborations in regulatory toxicological testing, viz., acute, sub-chronic and chronic toxicity testing. The departmental research activities are concentrated in the following areas:

  • Opioid tolerance, supersensitivity and dependence mechanisms
  • Role of different subtypes of angiotensin receptors in hypertension and diabetic vascular complications
  • Understanding the mechanisms of diabetic complication and development of NIDDM & insulin resistance models in rodents; screening of synthetic and natural products for their antidiabetic activity
  • Role of alpha adrenoceptors in benign prostatic hyperplasia
  • Understanding the molecular mechanisms involved in ischaemic stroke
  • Evaluation of novel neuroprotective approaches for the treatment of cerebral ischemia
  • Development of animal models of cerebral ischemia
  • Understanding the mechanisms of diabetic neuropathy
  • Role of adenosine receptors subtypes in diabetic neuropathic pain
  • Evaluation of various neuroprotective approaches in diabetic neuropathy
  • Screening of NCEs for antileismanial activity.
  • Development of rat model for Alzheimer's disease and screening of NCEs on learning and memory in rats
  • Production of monoclonal antibodies against Plasmodium yoelii nigeriensis antigens with the objective of characterization of protective antigens
  • Molecular mechanisms of protection, cytoadherence, immune evasion and red cell invasion in malaria
  • Biotherapeutics and chemotherapeutics evaluation of potential antimalarial, antitubercular, antileishmanial and antiamoebic agentsin vitro and in vivo
  • Study of the opioids-induced bidirectional molecular signaling within the neuroimmune network with a view to develop new immunomodulators.
  • Histone modifications as targets for drug discovery
  • Molecular mechanism involved in toxicant and oxidative stress induced process of cell death