The department started along with the establishment of NIPER-Hajipur from 2007. Biotechnology has application in almost every field of our life including medicine, pharmaceuticals, diagnostics, agriculture, environmental sciences, eco-friendly energy generation etc. Right from understanding the cause of disease, host pathogen interactions, progression of disease, and immune system of human body, to drug discovery and drug development, generation of recombinant therapeutic proteins & biopharmaceuticals biotechnology has important roles to play. The Department offers M.S. (Pharm.), Ph.D., and Postdoctoral research programs. The duration of M.S. (Pharm.) is of four semesters out of which the last two semesters are dedicated exclusively for research project. Subjects offered in first and second semesters include Microbial Genetics, Cell Biology, Biochemistry, Biostatistics, Biochemical Engineering Fundamentals, Separation Technique, Microbiology, Analysis; Diagnostics and Cell based Screening, Molecular Biology, Immunology and Immunotechnology, Sequence Analysis, Recombinant DNA Technology and Laboratory Experience in Specialized Area. This program covers the wide range of subjects that are important for preparing the students and enhancing their competence towards the needs of growing Pharmaceutical industry in India. The department has currently 19 MS students (2nd year). 7 Ph.D. and 1 research fellow in sponsored project.
Nanozyme development for biomedical applications
Recombinant DNA technology using bacterial, Pichia pastoris and Baculovirus expression systems
Novel approaches to regenerative medicine (tissue engineering)
3D organ development for replacement of animal models in drug screening
Nanoengineering of stem cells
Metallic nanoparticles for neglected tropical diseases and antifungal applications
Quantum dots –based drug delivery for antimicrobial resistance
Advanced biomaterials for treatments of colon and liver inflammations
The department has high-end instrument facilities including Dynamic Light scattering (DLS), Fourier transform-Infra red (FT-IR), Isothermal Calorimeter (ITC), High pressure Liquid Chromatography (HPLC) with PDA+UV detector, UV-visible spectrophotometer, Fluorescence Spectrophotometer, Nanoparticle tracking analyzer, Lyophilizer, Electrospining Machine for generation of Nanofibers from biomaterials, RT-PCR, Thermocycler, 3D organ culture facility with clean room, Mammalian cell culture with Biosafety cabinet and CO2 incubator, Laminar hood for bacterial and fungal culture etc.
The department also uses facilities from central instruments facility which comprises of LC-HRMS, Flash Chromatography; GC-MS triple Quadruple, Semi Preparative HPLC, differential scanning calorimeter (DSC), inductively coupled plasma mass spectrometry (ICP-MS), FACS-sorter. HPLC with ELSD, RI and fluorescence detector, etc.
The Institute is also in the process of purchasing Fast performance liquid Chromatography (FPLC), Circular Dichroism (CD) spectrometer, UHPLC, LC-MS triple Quadruple, Preparative HPLC, high speed floor model centrifuge, 600 mHz NMR, High resolution confocal microscope etc in next 6 months.
The Department Pharmacy Practice, at NIPER, HAJIPUR was established in the year 2007. The aim of the Department is to impart patient oriented pharmacy education and train the students in Pharmacy Practice on par with international standards; the primary goal of the department is to train the students preparing for careers in Pharmacy Practice including teaching and research in an academic or industrial setting or in pharmaceutical companies and government research organizations.
The department offers postgraduate M.Pharm. (Pharmacy Practice) and Doctoral (Pharmacy Practice) and post-Doctoral courses programmes. The Pharmacy Practice programme is run in collaboration with Mahavir Cancer Institute & Research Centre & Rajendra Memorial Research Institute of Medical Sciences (RMRIMS) in patna and promote quality education and research with Master's, Doctoral courses.
This course is designed to impart the basic knowledge and skills that are required to practice pharmacy including the provision of pharmaceutical care services to both healthcare professionals and patients in clinical settings.
This course aims to enable the students to understand the different treatment approaches in managing various disease conditions and optimizing drug therapy of a patient by individualizing the treatment plan through evidence-based medicines.
Provide the students an opportunity to learn drug development process especially the phases of clinical trials and also the ethical issues involved in the conduct of clinical research, designing, conducting and managing clinical trials.
The department intends to promote research and service, demonstrating excellence in professional practice and outreach. The department of pharmacy practice is committed to review the patient record and each prescription presented for supply for the purpose of promoting therapeutic appropriateness by indentifying : (i) Over utilization or under utilization (ii) Therapeutic duplication (iii) Drug-disease interactions (iv) Drug-drug interactions (v) Incorrect drug dosage or duration of drug treatment (vi) Drug-allergy interactions (vii) Correlation of availability of drugs (to avoid artificial shortage of drugs) (viii) Clinical abuse/misuse (ix) Promotion of rational drug use (x) Patient counseling.
Clinical and applied Therapeutics
Prescription-Event Monitoring (PEM)
Health related quality of life (HRQOL) & Clinical outcome
Causality assessment of adverse drug reactions
Bioavailability and Bioequivalence studies
Pharmacoepidemiology & Pharmacoeconomics
HPV and associated clinical outcomes
Evaluation of chemotherapy Induced Disease in cancer patients
Department of Pharmacology and Toxicology at NIPER, Hajipur was established in 2018. The department is research-oriented and offering training to postgraduate and PhD students to fulfil the national and international demand of trained pharmacologist. Since its inception, the department aspires to become a recognized Centre for the pharmacological and toxicological screening of products from various sources. The recent development is in the same line by the addition of a state of art laboratory with various instruments to perform basic to advance research. The department has good coordination with other research institutes namely Mahavir Cancer Institute and Research Centre, Patna, Rajendra Memorial Research Institute of Medical Sciences, Patna (previous mentor institute) and Central Drug Research Institute, Lucknow for various projects and study-related activities.
MS. Pharm (Pharmacology and Toxicology)
The duration of the postgraduate course is of 2 years spread over of 4 semesters, out of which the last two semesters are exclusively dedicated for the research project. The course curriculum is designed to cover the areas of the fundamental and regulatory aspect of safety, and efficacy of pharmaceutical products from herbal and synthetic sources.
Subjects in first semester:
Pathophysiology, General and Experimental Pharmacology, Chemotherapy of Parasitic and Microbial Infections, Separation Techniques, Biopharmaceutics and Pharmacokinetics, Biotechnology in Pharmaceutical Sciences, Biostatistics and Fundamentals of Intellectual Property (IP) and Technology Management.
Subjects in Second semester: Drug Metabolism, Pharmacological Screening and Assays, CNS and Respiratory Pharmacology, Autonomic, CVS, Blood, Renal and GI Pharmacology, Autacoid and Endocrine Pharmacology, Clinical Pharmacology, Regulatory Toxicology, Chemotherapy, Immunopharmacology.
Project work in third and fourth semester: Though the research training starts from the first semester onwards, the real research experience is imparted to students by the experienced faculty of NIPER, Hajipur and nearby reputed scientists of other national institutes in the second year. Students are given the freedom to select the research area while the emphasis is given to work in the area of expertise of the faculty.
In collaboration with biotechnology, dept of pharmacology and toxicology is developing pharmacologic, genetic and stem cell-based interventions for reversing mood and cognitive deficits in aging, Alzheimer’s disease, and diabetes or chemotherapy-induced brain disorders. This project focuses primarily on the functional and mechanistic aspects of stem cell biology and the potential of different types of stem cells for therapeutic applications.
Further, in collaboration pharmacy practice and analytical department, and IGIMS Patna, we aim to identify the simple, cost-effective, and easy-to-use biomarkers for detection, prognosis, and therapeutic assessment of neurological disorders, cancer, and diabetes.
Research in pharmacology and toxicology dept focuses on determining the epigenetic changes in diabetes and diabetic complications, and cardiovascular diseases, and determining whether these changes are sex-linked
The Department of Pharmaceutics was established in 2021, with the aim of quality research in pharmaceutical formulation and drug delivery which improves the learning and research abilities of the scholars. The research in this department imparts the quality of generic and specialty medicines. The department offers M.S (Pharm) and Doctor of Philosophy (Ph.D.) programs in Pharmaceutics. The department has proficient faculty and scholars continuously engaged in research activities for better delivery of therapeutics for improving safety and efficacy.The Department of Pharmaceutics is actively engaged in various research activities such as common research plans, industry-oriented research projects, and inter-departmental and inter-institutional research projects. The department has excellent infrastructural facilities planned for several high-end pharmaceutical characterization equipment including HPLC, BET, µ disso, LD, FTIR FPA CI, NTA, DSC, DLS, Rheometer, Texture analyzer, SPFA, UV-DRS-NIR spectrometer, Dissolution test apparatus (Type I, II, and IV) and Disintegration tester.The manufacturing facilities in the department include a wide range of cGMP dryers (FB and Lyo), advanced fluid bed processing, Mini Press II, Auto-coater, advanced milling, and particle size engineering, USFDA Medical Device Class I stability chambers, capsule manufacturing and filling facilities, semisolid manufacturing facilities, nano-enabled formulation development, and scale-up facilities.
To do cutting-edge research in pharmaceutics and drug delivery, which offers patient-friendly, accessible, and affordable quality pharmaceutical formulations for global healthcare needs.
Departmental research projects are focused on formulation development of modified release systems, nano-formulations for targeted drug delivery, topical formulations, peptide delivery systems, generic product development, etc. The research activities of the department are planned in different areas which include
Conventional, modified-release, site-specific, and targeted drug delivery systems.
Novel manufacturing techniques
Nano pharmaceutical delivery systems.
Peptide drug delivery systems.
Particle engineering and solubility enhancement of poorly water-soluble drugs.
Integrating QbD (DoE) approach in formulation development.
In-vitro & ex-vivo / in-vivo characterization of API & formulations.
Physiological-Based Pharmacokinetic Modeling and Simulations
Stability testing of API & formulations
The Pharmaceutics department has planned to develop advanced facilities for formulation research and manufacturing as per GMP requirements for quality research in areas of oral drug delivery, nano-enabled formulations, Long Acting Injectables (LAIs), and topical formulations.
Department has signed MoU with pharmaceutical industries such as Zuventus Health Ltd., Sirek Research, Biopin Ambal, and Divya Patent firm to strengthen the collaborative, research, sponsored / consultancy projects, training-placement, and internship activities, as well as for exchanging knowledge through industry expert talks.
The department of pharmaceutical analysis at NIPER-Hajipur started in the academic year (ACY) 2021-22 with M.S (Pharm.) and PhD degree in pharmaceutical analysis. The department also designated to serve as central analytical facility for other departments as facility support and inter-departmental research initiatives. The pharmaceutical analysis specialization focusses the science and skills in the new analytical method development and validationof procedure using different analytical principles like chromatography, spectroscopy, thermal methods etc., trouble shooting of analytical procedure, quality control of pharmaceuticals/nutraceuticals/phytopharmaceuticals. Our department striving for collaborative research in proteomics area for drug target validation, biomarkers discovery, chemoproteomics and post translational modification. In addition, the department also participating in establishing of “centre of excellence in biologics”for analytical characterization, stability and release. The department is pioneer in establishing analytical quality by design (AQbD) at par with the requirement of ICHQ14, stability studies, genotoxicity profiling, preclinical pharmacokinetics etc. The departmententitled to implement GMP/GLP practices.
The laboratory is established with adequate space including, Change room, Wet analysis laboratory, Sample preparation area, Central facility – 1 (LC-MS(Orbitrap)/ Proteomics lab), Central facility-2 (LC-MS/MS (QQQ), GC-MS/MS), Hazard Chemical zone (Fume Hood area), Chemicals storage area. The Laboratory implemented the minimum GLP requirements, SOPs, fire safety requirement, Log-books, exit-entry record, sample/standards storage record, calibration/maintenance record, PPE, Hazard disposal etc.
Committed to excel in analytical technology through adopting advanced technologies and shall endeavour to ensure the precise outcome for societal needed research in collaboration with stakeholders of health professionals.
LC-HRMS based proteomics profiling of microbial, animal tissue and human serum (ICMR-RMRIMS, Patna)
Metabolomics Data base development of C. elegans (Collaboration: Alagappa University).
Natural product profiling / identification secondary metabolite (Common research Plan: NIPER-G)
Nitrosamine control in Pharmaceutical products (NIPER-K).
Proteomics based drug mechanism study, and microbial/ cancer drug resistance.
Industry relevant analytical method development using LC-HRMS, HPLC/Prep. HPLC using AQbD/QSRR/ICHQ14.
Department of Regulatory Toxicology at NIPER, Hajipur was established in 2022. Since its inception, thedepartment is specialised in training post graduate students for Industry need keeping a focus on safely oftherapy at prime importance. It deals with training students for evaluating toxicity of NCE and drugspreclinically and clinically. The department is equipped with a state of art laboratory with various instrumentsto perform basic to advance research in toxicology with special focuss on molecular mechanism of toxicity.The department is working in coordination with Department of Pharmacology and toxicology inside thepremises and other research institutes namely Mahavir Cancer Institute and Research Centre, Patna,Rajendra Memorial Research Institute of Medical Sciences, Patna (previous mentor institute) and IGIMS,Patna for various projects and study-related activities.
MS. Pharm (Regulatory Toxicology)
The duration of the postgraduate course is of 2 years spreadover of 4 semesters, out of which the last two semesters are exclusively dedicated for the research project.The course curriculum is designed to cover the areas of the fundamental and regulatory aspect of safety, and efficacy of pharmaceutical products from herbal and synthetic sources.
Subjects in first semester:
Pathophysiology, General and Experimental Pharmacology, Chemotherapy of Parasitic andMicrobial Infections, Separation Techniques, Biopharmaceutics and Pharmacokinetics, Biotechnology inPharmaceutical Sciences, Biostatistics and Fundamentals of Intellectual Property (IP) and TechnologyManagement.
Subjects in Second semester: Drug Metabolism, Pharmacological Screening and Assays, CNS andRespiratory Pharmacology, Autonomic, CVS, Blood, Renal and GI Pharmacology, Autacoid and EndocrinePharmacology, Clinical Pharmacology, Regulatory Toxicology, Chemotherapy, Immunopharmacology.
Project work in third and fourth semester: Though the research training starts from the first semester onwards, the realresearch experience is imparted to students by the experienced faculty of NIPER, Hajipur and nearby reputedscientists of other national institutes in the second year. Students are given the freedom to select the researcharea while the emphasis is given to work in the area of expertise of the faculty.
Developing safety biomarkers in drug development, and pre-clinical risk assessment in regulatory toxicology.
Reproductive, mutagenicity, genotoxicity and carcinogenicity studies.
Toxicokinetics and toxicodynamics profile of nanoformulations / nanoparticles
Developing organoids (3D culture) for toxicology and genetic toxicology
Studying organ-specific toxicity using transcriptomics, proteomics and metabolomics.
Developing regulatory framework for nanoformulations, AYUSH drugs, and environmental pollutants.
Toxicity, mechanism and health effects of heavy metals, and Develop a QSTR model to predict neurotoxicity.
Toxicological studies of drugs and nanoformulations from herbal and synthetic sourcesNeurotoxicologyCardiovascular safety